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MK-677 (Ibutamoren)
MK-677 (Ibutamoren) is an oral growth hormone secretagogue studied for its ability to boost natural GH and IGF-1 levels, supporting body composition, recovery, sleep quality, and potential anti-aging effects.
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What is MK-677 (Ibutamoren)?
MK-677, also known as Ibutamoren, is a long-acting growth hormone secretagogue that stimulates the release of GH (growth hormone) and IGF-1 (insulin-like growth factor 1) by mimicking the action of ghrelin. Unlike injectable peptides, MK-677 is taken orally and has become a popular compound in research for its potential to improve body composition, recovery, sleep, and anti-aging outcomes.
Potential Benefits Shown in Studies
- Increasing natural GH and IGF-1 levels
- Promoting lean muscle mass and reducing fat
- Enhancing recovery, strength, and performance
- Improving deep sleep and sleep quality
- Supporting bone density and joint health
- Promoting healthy skin, hair, and tissue repair
- Supporting anti-aging and metabolic wellness
Mechanisms of Action
MK-677 works by:
- Binding to ghrelin receptors (GHSR-1a) in the brain
- Stimulating the natural release of growth hormone and IGF-1
- Extending GH release for over 24 hours with once-daily oral dosing
- Enhancing sleep quality, especially REM sleep
- Supporting tissue repair, fat loss, and lean muscle growth
Its oral bioavailability and long duration make it unique among GH-releasing compounds.
Molecular Structure of MK-677 (Ibutamoren)
Sequence
2-amino-2-methyl-N-[(2R)-1-(1H-indol-3-yl)propan-2-yl]-4-(naphthalen-1-yl)butanamide
Molecular Properties
MK-677 (Ibutamoren) Research Highlights
In aging individuals, daily oral MK‑677 significantly increases growth hormone and IGF‑1 levels to ranges typically seen in much younger adults, while maintaining stable cortisol profiles.
Source: J Clin Endocrinol Metab, 1996
A 12-month randomized controlled trial in older adults showed that MK‑677 increased lean mass and bone mineral density, demonstrating its anabolic potential.
Source: peptideswiki
In a controlled study, MK‑677 reversed the loss of body nitrogen in calorie-restricted individuals, indicating preservation of muscle protein and anti-catabolic properties.
Source: J Clin Endocrinol Metab, 1998
MK‑677 administration for one week in healthy adults led to improvements in sleep architecture, notably increasing rapid eye movement (REM) and slow-wave sleep stages.
Source: academic.oup
