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IGF-1 LR3
IGF-1 LR3 (Insulin-Like Growth Factor 1 Long Arg3) is a modified version of natural IGF-1, a hormone involved in growth and repair. The LR3 version has been altered to have a longer half-life and reduced binding to proteins in the body, making it more active and longer-lasting. It's often researched for its role in muscle growth, recovery, and cellular regeneration.
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All peptides arrive in powdered form for stability.
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Double-tested to ensure the highest quality for the most effective research.
What is IGF-1 LR3?
IGF-1 LR3 is a modified version of human Insulin-like Growth Factor 1 (IGF-1), designed to have a longer half-life and greater biological activity. The "LR3" version includes a substitution of arginine at position 3 and a 13-amino acid extension at the N-terminal, allowing it to remain active in the bloodstream significantly longer than native IGF-1.
This engineered peptide has been studied for its potential to enhance muscle growth, recovery, fat metabolism, and anti-aging processes.
Potential Benefits Shown in Studies
- Stimulating lean muscle growth and strength
- Enhancing muscle repair and recovery
- Supporting fat loss through increased energy use
- Promoting cell regeneration and tissue repair
- Improving bone density and joint health
- Supporting healthy aging and recovery in older adults
- Enhancing endurance and exercise performance
Mechanisms of Action
IGF-1 LR3 works by:
- Stimulating cellular growth and division via IGF-1 receptors
- Enhancing protein synthesis and muscle hypertrophy
- Activating satellite cells, essential for muscle repair
- Improving insulin sensitivity and glucose uptake
- Promoting fat breakdown while preserving lean mass
Its extended half-life (~20–30 hours vs. ~12–15 minutes in native IGF-1) makes it especially powerful in research settings.
Molecular Structure of IGF-1 LR3
Sequence
MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
Molecular Properties
Note: This version has a substitution of Arg (R) at position 3 and an extended N-terminal peptide chain.
IGF-1 LR3 Research Highlights
IGF‑1 LR3 features an arginine substitution at position 3 and a 13-amino-acid N‑terminal extension, making it approximately three times more potent than native IGF‑1, with a significantly longer circulating half-life of ~20–30 hours.
Source: wikipedia
IGF‑1 LR3 is widely used in lab models for studying cell proliferation, metabolic regulation, stem cell maintenance, and tissue regeneration due to its long-lasting bioactivity.
Source: tydes
