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Hexarelin
Hexarelin is a synthetic growth hormone secretagogue and part of the GHRP (Growth Hormone-Releasing Peptide) family. It works by stimulating the release of growth hormone (GH) through activation of the ghrelin receptor. Hexarelin is well-studied for its potent GH-releasing effects, as well as its potential to support muscle growth, fat loss, and cardiovascular health.
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What is Hexarelin?
Hexarelin is a synthetic growth hormone-releasing peptide (GHRP) composed of six amino acids. It mimics ghrelin, the body's natural "hunger hormone," and binds to the GHSR-1a receptor to stimulate the pituitary gland to release growth hormone (GH). Hexarelin is recognized for its strong GH release, muscle-building, fat-reducing, and cardioprotective properties in research models.
Potential Benefits Shown in Studies
- Increasing natural growth hormone and IGF-1 levels
- Supporting lean muscle growth and recovery
- Reducing body fat and improving metabolism
- Enhancing strength and physical performance
- Improving sleep and tissue regeneration
- Offering potential heart-protective effects (in animal studies)
- Promoting bone health and anti-aging benefits
Mechanisms of Action
Hexarelin works by:
- Stimulating pulsatile GH secretion from the pituitary
- Activating the ghrelin receptor (GHSR-1a) in the brain and heart
- Increasing IGF-1 production, promoting growth and repair
- Enhancing cardiac cell survival, protecting the heart from damage
- Boosting muscle growth, recovery, and lipolysis
Its potency is considered stronger than other GHRPs like GHRP-6 or GHRP-2.
Molecular Structure of Hexarelin
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂
Molecular Properties
Hexarelin Research Highlights
Hexarelin, also known as Examorelin, is a synthetic hexapeptide that binds with high affinity to growth hormone secretagogue receptors (GHS-R1a), significantly boosting growth hormone (GH) release in both animals and humans.
Source: wikipedia
Preclinical studies demonstrate that Hexarelin also binds to cardiac CD36 receptors and exerts GH-independent cardioprotective actions—such as improved myocardial contractility, reduced fibrosis, and enhanced cardiac performance post-ischemia.
Emerging research suggests Hexarelin activates intracellular signaling pathways such as PLC/PKC and AC/PKA, potentially contributing to neural health, metabolic regulation, and systemic homeostasis.
Source: newskarnataka
In research applications, Hexarelin promotes muscle and tendon repair, supports lipid metabolism, and may increase bone density through GH-mediated IGF‑1 pathway activation.
Source: peptides.org
