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KPV, 10mg
KPV (Lysine–Proline–Valine) is a short tripeptide studied for its potent anti-inflammatory properties. It works by inhibiting pro-inflammatory cytokines like TNF-α and IL-6, primarily through melanocortin receptor pathways. Research suggests KPV may help reduce inflammation in the gut, skin, and other tissues without suppressing the immune system.
Quantity: 1
All peptides arrive in powdered form for stability.
Third-Party Verified Purity
Each batch is tested and certified to meet or exceed 99% purity standards.
Made in the USA
Produced in United States WHO/GMP and ISO 9001:2015 certified facilities.
Rigorous Quality Control
Double-tested to ensure the highest quality for the most effective research.
What is KPV?
KPV (Lysine–Proline–Valine) is a naturally occurring tripeptide known for its strong anti-inflammatory effects. It works by interacting with melanocortin 1 receptors (MC1R) to inhibit key inflammatory pathways, including the suppression of cytokines like TNF-α, IL-6, and NF-κB. Unlike traditional anti-inflammatory drugs, KPV has shown the ability to reduce inflammation without broadly suppressing the immune system. Research has explored its therapeutic potential in conditions affecting the gut, skin, and other tissues where localized inflammation plays a role, making it a promising candidate for immune modulation and tissue recovery.
Potential Benefits Shown in Studies
Potential Benefits Shown in Studies – KPV
- Reduces inflammation by suppressing pro-inflammatory cytokines (e.g., TNF-α, IL-6)
- Modulates immune response without broad immunosuppression
- Calms inflammation in the gut, including models of colitis and IBD
- Supports skin healing and reduces inflammatory skin conditions
- Acts through melanocortin receptors to target localized inflammation
- May help protect tissues from chronic inflammatory damage
- Potential use in systemic and localized inflammatory conditions
Mechanisms of Action
Mechanism of Action – KPV
- Melanocortin Receptor Activation: Binds primarily to melanocortin 1 receptors (MC1R), which play a key role in regulating inflammation.
- NF-κB Inhibition: Suppresses nuclear factor kappa B (NF-κB), a central transcription factor involved in inflammatory cytokine production.
- Cytokine Modulation: Downregulates pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β.
- Localized Anti-Inflammatory Effects: Reduces inflammation at the tissue level without broadly suppressing systemic immune function.
- Supports Barrier Integrity: May help maintain epithelial barrier function in gut and skin by reducing inflammatory stress.
Molecular Structure of KPV
Sequence
Lys-Pro-Val
Molecular Properties
KPV Research Highlights
Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway
Source: pubmed
Transdermal Iontophoretic Delivery of Lysine-Proline-Valine (KPV) Peptide Across Microporated Human Skin
Source: pubmed
A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon
Source: pubmed